Investigating the protective effects of estrogen on β-cell health and the progression of hyperglycemia-induced atherosclerosis Journal Articles uri icon

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  • This study examines the effect(s) of estrogen on β cell and cardiometabolic health/function in a novel mouse model of hyperglycemia-induced atherosclerosis ( ApoE−/−: Ins2+/Akita). Using a combination of estrogen deprivation (ovariectomy) and supplementation strategies, we quantify effects on glucose homeostasis and atherogenesis. Our results clearly show a protective role for estrogen on pancreatic β-cell health and function and glucose homeostasis. Furthermore, estrogen supplementation dramatically reduces atherosclerosis progression in both male and female mice.


  • De Paoli, Monica
  • Wood, Dempsey W
  • Bohn, Mary K
  • Pandey, Arjun K
  • Borowitz, Dana K
  • Fang, Susanna
  • Patel, Zinal
  • Venegas-Pino, Daniel E
  • Shi, Yuanyuan
  • Werstuck, Geoff

publication date

  • September 1, 2022