Journal article
QSAR models reveal new EPAC-selective allosteric modulators
Abstract
Exchange proteins directly activated by cAMP (EPAC) are guanine nucleotide exchange factors for the small GTPases, Rap1 and Rap2. They regulate several physiological functions and mitigation of their activity has been suggested as a possible treatment for multiple diseases such as cardiomyopathy, diabetes, chronic pain, and cancer. Several EPAC-specific modulators have been developed, however studies that quantify their structure-activity …
Authors
Mohamed H; Shao H; Akimoto M; Darveau P; MacKinnon MR; Magolan J; Melacini G
Journal
RSC Chemical Biology, Vol. 3, No. 10, pp. 1230–1239
Publisher
Royal Society of Chemistry (RSC)
Publication Date
October 5, 2022
DOI
10.1039/d2cb00106c
ISSN
2633-0679