Determinants of antibody response to severe acute respiratory syndrome coronavirus 2 mRNA vaccines in people with HIV Journal Articles uri icon

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abstract

  • We identified determinants of SARS-CoV-2 mRNA vaccine antibody response in people with HIV (PWH). Antibody response was higher among PWH less than 60 years, with CD4+ cell count superior to 350 cells/μl and vaccinated with mRNA-1273 by Moderna compared with BNT162b2 by Pfizer-BioNTech. Preinfection with SARS-CoV-2 boosted the antibody response and smokers had an overall lower antibody response. Elderly PWH and those with low CD4+ cell count should be prioritized for booster vaccinations.

authors

  • Chammartin, Frédérique
  • Kusejko, Katharina
  • Pasin, Chloé
  • Trkola, Alexandra
  • Briel, Matthias
  • Amico, Patrizia
  • Stoekle, Marcel P
  • Eichenberger, Anna L
  • Hasse, Barbara
  • Braun, Dominique L
  • Schuurmans, Macé M
  • Müller, Thomas F
  • Tamm, Michael
  • Mueller, Nicolas J
  • Rauch, Andri
  • Koller, Michael T
  • Günthard, Huldrych F
  • Bucher, Heiner C
  • Speich, Benjamin
  • Abela, Irene A

publication date

  • August 1, 2022

published in