Morphine-Induced Attenuation of Morphine Tolerance Journal Articles

abstract

• Rats experienced both morphine and an environmental cue, but the cue always signaled a drug-free period. They were subsequently administered morphine in the presence of the cue, and the development of analgesic tolerance was assessed. The prior experience retarded such tolerance. The finding that a procedure of opiate administration can retard opiate tolerance suggests that an association between cues preceding the drug and the drug itself contributes to tolerance.

authors

• Siegel, Shepard
• Hinson, Riley E
• Krank, Marvin D

status

• published 

publication date

• June 26, 1981

has subject area

• Animals (MeSH)
• Conditioning, Operant (MeSH)
• Drug Tolerance (MeSH)
• General Science & Technology (Science Metrix)
• Light (MeSH)
• Morphine (MeSH)
• Rats (MeSH)

published in

• Science  Journal

keywords

• Animals
• Conditioning, Operant
• Drug Tolerance
• Light
• Morphine
• Rats

Digital Object Identifier (DOI)

• 10.1126/science.7233244

PubMed ID

• 7233244

start page

• 1533

end page

• 1534

volume

• 212

issue

• 4502