Morphine-induced attenuation of morphine tolerance Academic Article uri icon

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abstract

  • Rats experienced both morphine and an environmental cue, but the cue always signaled a drug-free period. They were subsequently administered morphine in the presence of the cue, and the development of analgesic tolerance was assessed. The prior experience retarded such tolerance. The finding that a procedure of opiate administration can retard opiate tolerance suggests that an association between cues preceding the drug and the drug itself contributes to tolerance.

publication date

  • June 26, 1981