Heroin "Overdose" Death: Contribution of Drug-Associated Environmental Cues Journal Articles

abstract

• A model of "overdose" deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug tolerance. Results of animal experiments performed to evaluate this model suggest that conditioned drug-anticipatory responses, in addition to pharmacological factors, affect heroin-induced mortality.

authors

• Siegel, Shepard
• Hinson, Riley E
• Krank, Marvin D
• McCully, Jane

status

• published 

publication date

• April 23, 1982

has subject area

• Animals (MeSH)
• Disease Models, Animal (MeSH)
• Dose-Response Relationship, Drug (MeSH)
• Drug Tolerance (MeSH)
• Environment (MeSH)
• General Science & Technology (Science Metrix)
• Heroin (MeSH)
• Humans (MeSH)
• Male (MeSH)
• Rats (MeSH)
• Substance-Related Disorders (MeSH)

published in

• Science  Journal

keywords

• Animals
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Drug Tolerance
• Environment
• Heroin
• Humans
• Male
• Rats
• Substance-Related Disorders

Digital Object Identifier (DOI)

• 10.1126/science.7200260

PubMed ID

• 7200260

start page

• 436

end page

• 437

volume

• 216

issue

• 4544