Diretrizes Brasileiras para o tratamento farmacológico de pacientes hospitalizados com COVID-19 Academic Article uri icon

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  • Objective

    Several therapies are being used or proposed for COVID-19, and many lack appropriate evaluations of their effectiveness and safety. The purpose of this document is to develop recommendations to support decisions regarding the pharmacological treatment of patients hospitalized with COVID-19 in Brazil.


    A group of 27 experts, including representatives of the Ministry of Health and methodologists, created this guideline. The method used for the rapid development of guidelines was based on the adoption and/or adaptation of existing international guidelines (GRADE ADOLOPMENT) and supported by the e-COVID-19 RecMap platform. The quality of the evidence and the preparation of the recommendations followed the GRADE method.


    Sixteen recommendations were generated. They include strong recommendations for the use of corticosteroids in patients using supplemental oxygen, the use of anticoagulants at prophylactic doses to prevent thromboembolism and the nonuse of antibiotics in patients without suspected bacterial infection. It was not possible to make a recommendation regarding the use of tocilizumab in patients hospitalized with COVID-19 using oxygen due to uncertainties regarding the availability of and access to the drug. Strong recommendations against the use of hydroxychloroquine, convalescent plasma, colchicine, lopinavir + ritonavir and antibiotics in patients without suspected bacterial infection and also conditional recommendations against the use of casirivimab + imdevimab, ivermectin and rendesivir were made.


    To date, few therapies have proven effective in the treatment of hospitalized patients with COVID-19, and only corticosteroids and prophylaxis for thromboembolism are recommended. Several drugs were considered ineffective and should not be used to provide the best treatment according to the principles of evidence-based medicine and promote economical resource use.


  • Falavigna, Maicon
  • Stein, Cinara
  • Amaral, José Luiz Gomes do
  • Azevedo, Luciano Cesar Pontes de
  • Belli, Karlyse Claudino
  • Colpani, Verônica
  • Cunha, Clóvis Arns da
  • Dal-Pizzol, Felipe
  • Dias, Maria Beatriz Souza
  • Ferreira, Juliana Carvalho
  • Freitas, Ana Paula da Rocha
  • Gräf, Débora Dalmas
  • Guimarães, Hélio Penna
  • Lobo, Suzana Margareth Ajeje
  • Monteiro, José Tadeu
  • Nunes, Michelle Silva
  • Oliveira, Maura Salaroli de
  • Prado, Clementina Corah Lucas
  • Santos, nia Cristina Canuto
  • Silva, Rosemeri Maurici da
  • Sobreira, Marcone Lima
  • Veiga, Viviane Cordeiro
  • Vidal, Ávila Teixeira
  • Xavier, Ricardo Machado
  • Zavascki, Alexandre Prehn
  • Machado, Flávia Ribeiro
  • Carvalho, Carlos Roberto Ribeiro de

publication date

  • 2022