Journal article
Lessening Organ Dysfunction With Vitamin C (LOVIT) Trial: Statistical Analysis Plan
Abstract
BACKGROUND: The LOVIT (Lessening Organ Dysfunction with Vitamin C) trial is a blinded multicenter randomized clinical trial comparing high-dose intravenous vitamin C to placebo in patients admitted to the intensive care unit with proven or suspected infection as the main diagnosis and receiving a vasopressor.
OBJECTIVE: We aim to describe a prespecified statistical analysis plan (SAP) for the LOVIT trial prior to unblinding and locking of the …
Authors
Adhikari NK; Pinto R; Day AG; Masse M-H; Ménard J; Sprague S; Annane D; Arabi YM; Battista M-C; Cohen D
Journal
JMIR Research Protocols, Vol. 11, No. 5,
Publisher
JMIR Publications
DOI
10.2196/36261
ISSN
1929-0748