WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations Academic Article uri icon

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abstract

  • While the degree of COVID-19 vaccine accessibility and uptake varies at both national and global levels, increasing vaccination coverage raises questions regarding the standard of prevention that ought to apply to different settings where COVID-19 vaccine trials are hosted. A WHO Expert Group has developed guidance on the ethical implications of conducting placebo-controlled trials in the context of expanding global COVID-19 vaccine coverage. The guidance also considers alternative trial designs to placebo controlled trials in the context of prototype vaccines, modified vaccines, and next generation vaccines.

authors

  • Singh, Jerome Amir
  • Kochhar, Sonali
  • Wolff, Jonathan
  • Atuire, Caesar
  • Bhan, Anant
  • Emanuel, Ezekiel
  • Faden, Ruth
  • Ghimire, Prakash
  • Greco, Dirceu
  • Ho, Calvin
  • Moon, Suerie
  • Shamsi-Gooshki, Ehsan
  • Touré, Aissatou
  • Thomé, Beatriz
  • Smith, Maxwell J
  • Upshur, Ross

publication date

  • March 2022