Journal article
Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin
Abstract
BACKGROUND: Uromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of uromodulin remain essentially unknown.
METHODS: We conducted a meta-analysis of genome-wide association studies for raw (uUMOD) and indexed to creatinine (uUCR) urinary levels of uromodulin in 29,315 individuals of European ancestry from 13 cohorts. We tested the …
Authors
Joseph CB; Mariniello M; Yoshifuji A; Schiano G; Lake J; Marten J; Richmond A; Huffman JE; Campbell A; Harris SE
Journal
Journal of the American Society of Nephrology, Vol. 33, No. 3, pp. 511–529
Publisher
Wolters Kluwer
Publication Date
March 2022
DOI
10.1681/asn.2021040491
ISSN
1046-6673