Evidence that axoplasmic transport of trophic factors is involved in the regulation of peripheral nerve fields in salamanders

1. We have compared the effects of partial denervation with those of colchicine-induced block of axoplasmic flow, on the peripheral fields of nerves innervating the hind limb of salamanders.2. Acute application of colchicine solution (0.03-0.10 M) to spinal nerve 16 results in a dose-dependent increase in skin and muscle fields of the adjacent nerves (15 and 17). The time course, magnitude and distribution of the response to 0.10 M colchicine …