Polygenic risk score for Alzheimer’s disease in Caribbean Hispanics

Polygenic risk scores (PRS) provide an overall estimate of the individual’s genetic propensity to a trait by combining sparse information scattered across multiple genetic loci which often display small effect sizes. Most genetic studies are of European ancestry, ultimately limiting the use of PRS in other ethnicities. Here we constructed and validated a PRS for late‐onset Alzheimer’s Disease (LOAD) in Caribbean Hispanics (CH). We employed …