Secondary Analysis of a Systematic Review: Are Antifungal Noninferiority Trials at Risk of Eroding Effectiveness Because of Biocreep? Journal Articles uri icon

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abstract

  • Non-inferiority randomized controlled trial (RCT) effectiveness may erode when results favor the active control over time, and when a decreasingly effective control arm is used in serial trials. We analyzed 32 antifungal noninferiority RCTs (NI-RCTs) for these scenarios in this secondary analysis of a systematic review.

publication date

  • January 18, 2022