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GLP-1 receptor agonist versus DPP-4 inhibitor and...
Journal article

GLP-1 receptor agonist versus DPP-4 inhibitor and kidney and cardiovascular outcomes in clinical practice in type-2 diabetes

Abstract

Whether glucagon-like peptide-1 receptor agonists (GLP1-RA) reduce detrimental kidney outcomes is uncertain. In secondary analyses, trials have shown consistent reductions in macroalbuminuria, but inconclusive results about kidney function decline. To help clarify this, we conducted a cohort study to compare kidney and cardiovascular outcomes in individuals who started GLP1-RA or dipeptidyl peptidase-4 inhibitors (DPP4i) (reduces degradation of …

Authors

Xu Y; Fu EL; Clase CM; Mazhar F; Jardine MJ; Carrero JJ

Journal

Kidney International, Vol. 101, No. 2, pp. 360–368

Publisher

Elsevier

Publication Date

February 2022

DOI

10.1016/j.kint.2021.10.033

ISSN

0085-2538