Journal article
Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection
Abstract
We have previously developed a robust regimen for tolerance induction in murine models of islet cell transplantation using pre- and posttransplant infusions of donor splenocytes (SPs) treated with a chemical cross-linker ethylcarbodiimide (ECDI). However, the requirement for large numbers of fresh donor SPs for ECDI coupling impairs its clinical feasibility, and additionally, the compatibility of this tolerance regimen with commonly used …
Authors
Wang S; Zhang X; Zhang L; Bryant J; Kheradmand T; Hering BJ; Miller SD; Luo X
Journal
Cell Transplantation, Vol. 24, No. 6, pp. 1155–1165
Publisher
SAGE Publications
Publication Date
June 2015
DOI
10.3727/096368914x681027
ISSN
0963-6897