Journal article
Coronary β2-adrenoreceptors mediate endothelium-dependent vasoreactivity in humans: novel insights from an in vivo intravascular ultrasound study
Abstract
AIMS: The interaction between coronary β(2)-adrenoreceptors and segmental plaque burden is complex and poorly understood in humans. We aimed to validate intracoronary (IC) salbutamol as a novel endothelium-dependent vasodilator utilizing intravascular ultrasound (IVUS), and thus assess relationships between coronary β(2)-adrenoreceptors, regional plaque burden and segmental endothelial function.
METHODS AND RESULTS: In 29 patients with …
Authors
Puri R; Liew GYH; Nicholls SJ; Nelson AJ; Leong DP; Carbone A; Copus B; Wong DTL; Beltrame JF; Worthley SG
Journal
European Heart Journal, Vol. 33, No. 4, pp. 495–504
Publisher
Oxford University Press (OUP)
Publication Date
February 1, 2012
DOI
10.1093/eurheartj/ehr359
ISSN
0195-668X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adrenergic beta-2 Receptor AgonistsAlbuterolCoronary CirculationDose-Response Relationship, DrugEndothelium, VascularFemaleHumansMaleMicrocirculationMicrovascular AnginaMiddle AgedNitric OxideObserver VariationPlaque, AtheroscleroticReceptors, Adrenergic, beta-2Ultrasonography, InterventionalVasodilator Agentsomega-N-Methylarginine