Journal article
GSPE Inhibits HMGB1 Release, Attenuating Renal IR-Induced Acute Renal Injury and Chronic Renal Fibrosis
Abstract
Grape seed proanthocyanindin extract (GSPE) is a polyphenolic bioflavonoid derived from grape seeds and has been widely studied for its potent antioxidant, anti-inflammatory and antitumor activities. HMGB1 is a newly discovered danger-associated molecular pattern (DAMP) that has potent proinflammatory effects once released by necrotic cells. However, the effect of GSPE on the HMGB1, and the relationship of those two with acute kidney injury and …
Authors
Zhan J; Wang K; Zhang C; Zhang C; Li Y; Zhang Y; Chang X; Zhou Q; Yao Y; Liu Y
Journal
International Journal of Molecular Sciences, Vol. 17, No. 10,
Publisher
MDPI
DOI
10.3390/ijms17101647
ISSN
1661-6596