Journal article
High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using 18F-ASEM PET
Abstract
Emerging evidence supports a hypothesized role for the α7-nicotinic acetylcholine receptor (α7-nAChR) in the pathophysiology of Alzheimer's disease. 18F-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-18F-fluorodibenzo[b,d]thiophene 5,5-dioxide) is a radioligand for estimating the availability of α7-nAChR in the brain in vivo with PET. Methods: In this cross-sectional study, 14 patients with mild cognitive impairment (MCI), a prodromal stage to …
Authors
Coughlin JM; Rubin LH; Du Y; Rowe SP; Crawford JL; Rosenthal HB; Frey SM; Marshall ES; Shinehouse LK; Chen A
Journal
Journal of Nuclear Medicine, Vol. 61, No. 3, pp. 423–426
Publisher
Society of Nuclear Medicine
Publication Date
March 2020
DOI
10.2967/jnumed.119.230979
ISSN
0161-5505