Journal article
Dose– and time–response relationships for lethal mutations and chromosomal instability induced by ionizing radiation in an immortalized human keratinocyte cell line
Abstract
PURPOSE: To investigate the relationship between two well-established delayed effects of ionizing radiation, experiments were conducted to determine the induction and expression of lethal mutations (delayed reproductive death) and chromosomal instability with respect to dose and time in a human immortalized keratinocyte cell line.
METHODS: HPV-G cells were gamma- or alpha-irradiated and maintained in culture for up to 72 population doublings. …
Authors
Mothersill C; Kadhim MA; O'Reilly S; Papworth D; Marsden SJ; Seymour CB; Wright EG
Journal
International Journal of Radiation Biology, Vol. 76, No. 6, pp. 799–806
Publisher
Taylor & Francis
Publication Date
January 2000
DOI
10.1080/09553000050028959
ISSN
0955-3002