Production of diverse PET probes with limited resources: 24 18 F-labeled compounds prepared with a single radiosynthesizer Academic Article uri icon

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  • Significance Molecular imaging with PET can provide a dynamic, whole-body picture of the rate of biological processes or distribution of biological targets by tracking the distribution of radiolabeled molecules or particles in the body over time. Continual efforts to develop new PET probes are expanding the variety of processes and targets that can be visualized, facilitating basic research, drug development, and patient care. However, access to these probes at all stages of their development is hindered by high costs arising, in large part, from the significant resources that are typically dedicated to production of a single probe. Emerging technologies with increased synthesis flexibility are allowing increased probe diversity with fewer resources and could significantly increase access to new molecular imaging agents.


  • Collins, Jeffrey
  • Waldmann, Christopher M
  • Drake, Christopher
  • Slavik, Roger
  • Ha, Noel S
  • Sergeev, Maxim
  • Lazari, Mark
  • Shen, Bin
  • Chin, Frederick T
  • Moore, Melissa
  • Sadeghi Hosseini, Seyed Saman
  • Phelps, Michael E
  • Murphy, Jennifer M
  • van Dam, R Michael

publication date

  • October 24, 2017