Preterm birth prevention in twin pregnancies with progesterone, pessary, or cerclage: a systematic review and meta‐analysis
Journal Articles
Overview
Research
Identity
Additional Document Info
View All
Overview
abstract
BackgroundAbout half of twin pregnancies deliver preterm, and it is unclear whether any intervention reduces this risk.ObjectivesTo assess the evidence for the effectiveness of progesterone, cerclage, and pessary in twin pregnancies.Search strategyWe searched Medline, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, and ISI Web of Science, without language restrictions, up to 25 January 2016.Selection criteriaRandomised controlled trials of progesterone, cerclage, or pessary for preventing preterm birth in women with twin pregnancies, without symptoms of threatened preterm labour.Data collection and analysisTwo independent reviewers extracted data using a piloted form. Study quality was appraised with the Cochrane Risk of Bias tool. We performed pairwise inverse variance random‐effects meta‐analyses.Main resultsWe included 23 trials (all but three were considered to have a low risk of bias) comprising 6626 women with twin pregnancies. None of the interventions significantly reduced the risk of preterm birth overall at <34 or <37 weeks of gestation, or neonatal death, our primary outcomes, compared to a control group. In women receiving vaginal progesterone, the relative risk (RR) of preterm birth <34 weeks of gestation was 0.82 (95% CI 0.64–1.05, seven studies, I2 36%), with a significant reduction in some key secondary outcomes, including very low birthweight (<1500 g, RR 0.71, 95% CI 0.52–0.98, four studies, I2 46%) and mechanical ventilation (RR 0.61, 95% CI 0.45–0.82, four studies, I2 22%).ConclusionIn twin gestations, although no overarching intervention was beneficial for the prevention of preterm birth and its sequelae, vaginal progesterone improved some important secondary outcomes.Tweetable abstractVaginal progesterone may be beneficial in twin pregnancies, but not 17‐OHPC, cerclage, or pessary.
