Journal article
Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching
Abstract
Two programs, GRAPE and GARLIC, work together to first predict biosynthetic gene clusters responsible for the production of polyketides and nonribosomal peptides, then link sequenced gene clusters to known and unknown natural products.
Authors
Dejong CA; Chen GM; Li H; Johnston CW; Edwards MR; Rees PN; Skinnider MA; Webster ALH; Magarvey NA
Journal
Nature Chemical Biology, Vol. 12, No. 12, pp. 1007–1014
Publisher
Springer Nature
Publication Date
December 2016
DOI
10.1038/nchembio.2188
ISSN
1552-4450