Polyketide and nonribosomal peptide...

Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching

Abstract

Two programs, GRAPE and GARLIC, work together to first predict biosynthetic gene clusters responsible for the production of polyketides and nonribosomal peptides, then link sequenced gene clusters to known and unknown natural products.

Authors

Dejong CA; Chen GM; Li H; Johnston CW; Edwards MR; Rees PN; Skinnider MA; Webster ALH; Magarvey NA

Journal

Nature Chemical Biology, Vol. 12, No. 12, pp. 1007–1014

Publisher

Springer Nature

Publication Date

December 1, 2016

DOI

10.1038/nchembio.2188

ISSN

1552-4450

Associated Experts

Nathan Magarvey

Associate Professor, Faculty of Health Sciences

Visit profile

Labels