Journal article
Identification of Conflicting Selective Effects on Highly Expressed Genes
Abstract
Many different selective effects on DNA and proteins influence the frequency of codons and amino acids in coding sequences. Selection is often stronger on highly expressed genes. Hence, by comparing high- and low-expression genes it is possible to distinguish the factors that are selected by evolution. It has been proposed that highly expressed genes should (i) preferentially use codons matching abundant tRNAs (translational efficiency), (ii) …
Authors
Higgs PG; Hao W; Golding GB
Journal
Evolutionary Bioinformatics, Vol. 3, ,
Publisher
SAGE Publications
Publication Date
January 2007
DOI
10.1177/117693430700300015
ISSN
1176-9343