Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trial

Background: It is unknown whether fluid resuscitation with colloid or crystalloid in patients with severe sepsis or septic shock is associated with an improvement in clinical outcome. This randomized controlled trial determined the feasibility of conducting a large trial testing resuscitation with pentastarchvs normal saline in early septic shock, powered for a difference in mortality.Methods: At three Canadian and one New Zealand academic …