Journal article
Semliki Forest virus and Kunjin virus RNA replicons elicit comparable cellular immunity but distinct humoral immunity
Abstract
RNA replicons offer a number of qualities which make them attractive as vaccination vectors. Both alphavirus and flavivirus replicon vaccines have been investigated in preclinical models yet there has been little direct comparison of the two vector systems. To determine whether differences in the biology of the two vectors influence immunogenicity, we compared two prototypic replicon vectors based on Semliki Forest virus (SFV) (alphavirus) and …
Authors
Tannis LL; Gauthier A; Evelegh C; Parsons R; Nyholt D; Khromykh A; Bramson JL
Journal
Vaccine, Vol. 23, No. 33, pp. 4189–4194
Publisher
Elsevier
Publication Date
July 21, 2005
DOI
10.1016/j.vaccine.2005.04.005
ISSN
0264-410X