Journal article
MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis
Abstract
Virtually all of the elements of Mycobacterium tuberculosis (Mtb) pathogenesis, including pro-inflammatory cytokine production, granuloma formation, cachexia, and mortality, can be induced by its predominant cell wall glycolipid, trehalose 6,6'-dimycolate (TDM/cord factor). TDM mediates these potent inflammatory responses via interactions with macrophages both in vitro and in vivo in a myeloid differentiation factor 88 (MyD88)-dependent manner …
Authors
Bowdish DME; Sakamoto K; Kim M-J; Kroos M; Mukhopadhyay S; Leifer CA; Tryggvason K; Gordon S; Russell DG
Journal
PLOS Pathogens, Vol. 5, No. 6,
Publisher
Public Library of Science (PLoS)
Publication Date
June 2009
DOI
10.1371/journal.ppat.1000474
ISSN
1553-7366
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AnimalsCHO CellsCord FactorsCricetinaeCricetulusCytokinesCytoplasmHumansLipopolysaccharide ReceptorsMacrophagesMiceMice, Inbred C57BLMicroscopy, FluorescenceMicrospheresMycobacterium tuberculosisPhagosomesReceptors, ImmunologicScavenger Receptors, Class ASignal TransductionToll-Like Receptor 2Toll-Like Receptor 4