Journal article
Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children
Abstract
Although the microneutralization (MN) assay has been shown to be more sensitive than the hemagglutination inhibition (HAI) assay for the measurement of humoral immunity against influenza viruses, further evidence relating MN titres to protective efficacy against infection is needed. Serum antibodies against seasonal H1N1 and H3N2 influenza were measured in children and adolescents (n = 656) by MN and hemagglutination inhibition (HAI) assays. …
Authors
Verschoor CP; Singh P; Russell ML; Bowdish DME; Brewer A; Cyr L; Ward BJ; Loeb M
Journal
PLOS ONE, Vol. 10, No. 6,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0131531
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAlbertaAntibodies, ViralAntibody FormationChildChild, PreschoolHemagglutination Inhibition TestsHemagglutinin Glycoproteins, Influenza VirusHumansImmunity, HumoralInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza VaccinesInfluenza, HumanManitobaNeutralization TestsPolymerase Chain ReactionProspective Studies