Conference
Leveraging amino acid sensors as therapeutic targets for tauopathies and related dementias
Abstract
Abstract Background Tauopathies including Alzheimer’s disease (AD) comprise of over 27 neurodegenerative diseases. Our group has uncovered a unique interaction between uncoupling of amino acid sensors and tauopathies. L‐Arginine metabolism impacts multiple processes that seemingly show considerable influence upon tau biology. Several protein sensors have been identified that sense arginine within the lysosomal lumen, cytoplasm and signal to …
Authors
Lee DC; Ma C; Morgan D; Liang H; Kovalenko A; Sandusky‐Beltran LA; Calahatian JI; Kallupurackal M; Hunt JB; Pandey S
Volume
16
Publisher
Wiley
Publication Date
December 2020
DOI
10.1002/alz.043859
Conference proceedings
Alzheimer's & Dementia
Issue
S2
ISSN
1552-5260