Journal article
A Model for the Ultrastructure of Bone Based on Electron Microscopy of Ion-Milled Sections
Abstract
The relationship between the mineral component of bone and associated collagen has been a matter of continued dispute. We use transmission electron microscopy (TEM) of cryogenically ion milled sections of fully-mineralized cortical bone to study the spatial and topological relationship between mineral and collagen. We observe that hydroxyapatite (HA) occurs largely as elongated plate-like structures which are external to and oriented parallel …
Authors
McNally EA; Schwarcz HP; Botton GA; Arsenault AL
Journal
PLOS ONE, Vol. 7, No. 1,
Publisher
Public Library of Science (PLoS)
Publication Date
2012
DOI
10.1371/journal.pone.0029258
ISSN
1932-6203