Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function Journal Articles uri icon

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abstract

  • The distribution of ionizable amino lipids (KC2) is critical in structure of lipid nanoparticles, siRNA entrapment and endosomal release. Neutral KC2 segregates from phospholipids (POPC) and forms an oily core in the bilayer interior.

authors

  • Ramezanpour, M
  • Schmidt, Miranda
  • Bodnariuc, I
  • Kulkarni, JA
  • Leung, SSW
  • Cullis, PR
  • Thewalt, JL
  • Tieleman, DP

publication date

  • August 1, 2019