Warfarin Therapy and Risk of Hip Fracture Among Elderly Patients Academic Article uri icon

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  • Study objective

    To ascertain the relationship between warfarin therapy and subsequent hip fracture in a large elderly population.


    Retrospective, population-based cohort study.


    Population-based health care administrative databases for Ontario, Canada.


    Elderly patients receiving warfarin (52,701 patients), thyroid replacement therapy (40,555), an oral corticosteroid (43,915), or a proton pump inhibitor (60,383). The proton pump inhibitor group served as controls.

    Measurements and main results

    The association between warfarin therapy and subsequent hospitalization for hip fracture in elderly patients was examined by researching administrative data from January 1, 1994-March 31, 1999, for the elderly population of Ontario. Relative to patients receiving proton pump inhibitors, patients receiving warfarin (adjusted risk ratio [aRR] 0.94, 95% confidence interval [CI] 0.81-1.09) or thyroid replacement therapy (aRR 1.02, 95% Cl 0.89-1.18) incurred similar risks of hip fracture. As expected, patients receiving oral corticosteroids incurred an increased risk (aRR 1.44, 95% CI 1.21-1.70) relative to patients receiving proton pump inhibitors.


    Warfarin was not associated with increased risk of hip fracture.


  • Mamdani, Muhammad
  • Upshur, Ross
  • Anderson, Geoff
  • Bartle, Bill R
  • Laupacis, Andreas

publication date

  • January 2003