Mitochondrial dysfunction is associated with a pro-apoptotic cellular environment in senescent cardiac muscle

Cardiac muscle undergoes significant remodeling with aging. This may be partly due to the progressive impairment of mitochondrial biogenesis and function. Our purpose was to examine how aging affects the subcellular localization of apoptogenic factors involved in mitochondrially mediated cell death in cardiac muscle. Employing 6- and 36-month-old Fischer 344xBN animals, we assessed markers of organelle content and function, as well as the …