Journal article
Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
Abstract
BACKGROUND: C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels.
METHODS AND RESULTS: We performed a genome-wide association analysis of CRP in 66 185 participants from 15 population-based studies. We sought replication for the genome-wide significant and suggestive loci in a replication panel …
Authors
Dehghan A; Dupuis J; Barbalic M; Bis JC; Eiriksdottir G; Lu C; Pellikka N; Wallaschofski H; Kettunen J; Henneman P
Journal
Circulation, Vol. 123, No. 7, pp. 731–738
Publisher
Wolters Kluwer
Publication Date
February 22, 2011
DOI
10.1161/circulationaha.110.948570
ISSN
0009-7322