Association of Variation at the
ABO
Locus With Circulating Levels of Soluble Intercellular Adhesion Molecule-1, Soluble P-selectin, and Soluble E-selectin
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abstract
Background—
Circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin have been associated with variation at the
ABO
locus. To evaluate these associations and the effect sizes, we performed a meta-analysis with new and previous reported data for polymorphism rs579459.
Methods and Results—
Compared with major allele homozygotes, heterozygotes and minor allele homozygotes had 4.6% (95% CI, 3.4%–5.8%,
P
=7.3×10
−14
) and 7.2% (95% CI, 4.7%–9.7%,
P
=1.5×10
−8
), respectively, lower soluble intercellular adhesion molecule-1 levels (n=33 671). An allele dose-dependent association also was observed for soluble P-selectin (n=4921) with heterozygotes and minor allele homozygotes having 11.5% (95% CI, 7.2%–15.8%,
P
=1.7×10
−7
) and 18.6% (95% CI, 9.1%–28.1%,
P
=1.2×10
−4
), respectively, lower levels than in major allele homozygotes. A larger effect size, again consistent with an additive genetic model, was seen for soluble E-selectin (n=2860) whose level was 25.6% (95% CI, 19.0%–32.2%,
P
=2.1×10
−14
) lower in heterozygotes and 43.3% (95% CI, 36.9%–49.3%,
P
=4.3×10
−42
) lower in minor allele homozygotes than in major allele homozygotes.
Conclusions—
The data support the association of variation at the
ABO
locus with soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin levels.
