Journal article
Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding
Abstract
BACKGROUND: Fixed-dose unmonitored treatment with dabigatran etexilate is effective and has a favorable safety profile in the prevention of stroke in atrial fibrillation patients compared with warfarin. We hypothesized that genetic variants could contribute to interindividual variability in blood concentrations of the active metabolite of dabigatran etexilate and influence the safety and efficacy of dabigatran.
METHODS AND RESULTS: We …
Authors
Paré G; Eriksson N; Lehr T; Connolly S; Eikelboom J; Ezekowitz MD; Axelsson T; Haertter S; Oldgren J; Reilly P
Journal
Circulation, Vol. 127, No. 13, pp. 1404–1412
Publisher
Wolters Kluwer
Publication Date
April 2, 2013
DOI
10.1161/circulationaha.112.001233
ISSN
0009-7322