Polygenic risk score predicts prevalence of cardiovascular disease in patients with familial hypercholesterolemia

Abstract

BACKGROUND: Although familial hypercholesterolemia (FH) is a severe monogenic disease, it has been shown that clinical risk factors and common genetic variants can modify cardiovascular disease (CVD) risk. OBJECTIVE: The aim of the study was to evaluate the polygenic contribution to lipid traits and CVD in FH using genetic risk scores (GRSs).

Authors

Paquette M; Chong M; Thériault S; Dufour R; Paré G; Baass A

Journal

Journal of Clinical Lipidology, Vol. 11, No. 3, pp. 725–732.e5

Publisher

Elsevier

Publication Date

May 2017

DOI

10.1016/j.jacl.2017.03.019

ISSN

1933-2874

Associated Experts

Guillaume Pare

Professor, Faculty of Health Sciences

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