Journal article
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells
Abstract
Human embryonic stem cells (hESCs) randomly differentiate into multiple cell types during embryoid body (EB) development. To date, characterization of specific factors capable of influencing hematopoietic cell fate from hESCs remains elusive. Here, we report that the treatment of hESCs during EB development with a combination of cytokines and bone morphogenetic protein-4 (BMP-4), a ventral mesoderm inducer, strongly promotes hematopoietic …
Authors
Chadwick K; Wang L; Li L; Menendez P; Murdoch B; Rouleau A; Bhatia M
Journal
Blood, Vol. 102, No. 3, pp. 906–915
Publisher
American Society of Hematology
Publication Date
August 1, 2003
DOI
10.1182/blood-2003-03-0832
ISSN
0006-4971