Journal article
Endothelial and Hematopoietic Cell Fate of Human Embryonic Stem Cells Originates from Primitive Endothelium with Hemangioblastic Properties
Abstract
The cellular organization and relationships among precursors that initiate embryonic angiogenesis and hematopoiesis in the human have yet to be characterized. Here, we identify a subpopulation of primitive endothelial-like cells derived from human embryonic stem cells (hESCs) that express PECAM-1, Flk-1, and VE-cadherin, but not CD45 (CD45negPFV cells), and that are uniquely responsible for endothelial and hematopoietic development. Molecular …
Authors
Wang L; Li L; Shojaei F; Levac K; Cerdan C; Menendez P; Martin T; Rouleau A; Bhatia M
Journal
Immunity, Vol. 21, No. 1, pp. 31–41
Publisher
Elsevier
Publication Date
July 2004
DOI
10.1016/j.immuni.2004.06.006
ISSN
1074-7613