Journal article
Foundational concepts of cell fate conversion to the hematopoietic lineage
Abstract
Direct conversion of cellular fate provides a potential approach to generate cells of the hematopoietic lineage without the requisite reversion to a pluripotent state via somatic cell reprogramming. The utilization of this technology has enabled transcription factor-mediated conversion of somatic cell types to primitive and mature hematopoietic cells. Recent studies demonstrate that the direct conversion of somatic cells to the hematopoietic …
Authors
Salci KR; McIntyre BA; Bhatia M
Journal
Current Opinion in Genetics & Development, Vol. 23, No. 5, pp. 585–590
Publisher
Elsevier
Publication Date
October 2013
DOI
10.1016/j.gde.2013.04.007
ISSN
0959-437X