Evans Syndrome in the Adolescent Female

Evans syndrome (ES) describes an immune dysregulation syndrome manifesting as multilineage autoimmune cytopenias, most often autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP), but also autoimmune neutropenia (AIN) in some cases. Since Evans and colleagues first described this phenomenon in the 1940s–1950s, this syndrome of immune cytopenias is increasingly identified to be secondary to underlying systemic immune dysregulation …