Pentosidine as a Biomarker for Poor Bone Quality and Elevated Fracture Risk

The purpose of this chapter is to explore the concept of pentosidine, an advanced glycation end product, as a biomarker of bone quality and bone fragility. Bone quality is a term used to describe the many factors that contribute to fracture risk that are not necessarily captured during clinical fracture assessment. Pentosidine formation in the body requires glycation and oxidation of proteins. In bone, the protein that is most affected is type …