Journal article
In Vitro Selection of Circular DNA Aptamers for Biosensing Applications
Abstract
Abstract We report on the first effort to select DNA aptamers from a circular DNA library, which resulted in the discovery of two high‐affinity circular DNA aptamers that recognize the glutamate dehydrogenase (GDH) from Clostridium difficile, an established antigen for diagnosing Clostridium difficile infection (CDI). One aptamer binds effectively in both the circular and linear forms, the other is functional only in the circular configuration. …
Authors
Liu M; Yin Q; Chang Y; Zhang Q; Brennan JD; Li Y
Journal
Angewandte Chemie, Vol. 131, No. 24, pp. 8097–8101
Publisher
Wiley
Publication Date
June 11, 2019
DOI
10.1002/ange.201901192
ISSN
0044-8249