This paper proposes a domain-centralized powertrain E/E (electrical and/or electronic) architecture for all-electric vehicles that features: a powerful master controller (domain controller) that implements most of the functionality of the domain; a set of smart actuators for electric motor(s), HV (High Voltage) battery pack, and thermal management; and a gateway that routes all hardware signals, including digital and analog I/O, and field bus signals between the domain controller and the rest of the vehicle that is outside of the domain. Major functional safety aspects of the architecture are presented and a safety architecture is proposed. The work represents an early E/E architecture proposal. In particular, detailed partitioning of software components over the domain’s Electronic Control Units (ECUs) has not been determined yet; instead, potential partitioning schemes are discussed. A thorough evaluation of the architecture, based on a hardware prototype and in-vehicle analysis, is forthcoming.