Multi-parameter water quality monitoring is crucial in resource-limited areas to provide persistent water safety. Conventional water monitoring techniques are time-consuming, require skilled personnel, are not user-friendly and are incompatible with operating on-site. Here, we develop a multi-parameter water quality monitoring system (MWQMS) that includes an array of low-cost, easy-to-use, high-sensitivity electrochemical sensors, as well as custom-designed sensor readout circuitry and smartphone application with wireless connectivity. The system overcomes the need of costly laboratory-based testing methods and the requirement of skilled workers. The proposed MWQMS system can simultaneously monitor pH, free chlorine, and temperature with sensitivities of 57.5 mV/pH, 186 nA/ppm and 16.9 mV/°C, respectively, as well as sensing of BPA with <10 nM limit of detection. The system also provides seamless interconnection between transduction of the sensors’ signal, signal processing, wireless data transfer and smartphone app-based operation. This interconnection was accomplished by fabricating nanomaterial and carbon nanotube-based sensors on a common substrate, integrating these sensors to a readout circuit and transmitting the sensor data to an Android application. The MWQMS system provides a general platform technology where an array of other water monitoring sensors can also be easily integrated and programmed. Such a system can offer tremendous opportunity for a broad range of environmental monitoring applications.