Journal article
Response to pregabalin and progesterone differs in male and female rat models of neuropathic and cancer pain
Abstract
Background: Cancer pain involves nervous system damage and pathological neurogenesis. Neuropathic pain arises from damage to the nervous system and is driven by ectopic signaling. Both progesterone and pregabalin are neuroprotective in animal models, and there is evidence that both drugs bind to and inhibit voltage-gated calcium channels. Aims: This study was designed to characterize the effects of progesterone and pregabalin in preclinical …
Authors
Ungard RG; Zhu YF; Yang S; Nakhla P; Parzei N; Zhu KL; Singh G
Journal
Canadian Journal of Pain, Vol. 4, No. 1, pp. 39–58
Publisher
Taylor & Francis
Publication Date
January 1, 2020
DOI
10.1080/24740527.2020.1724776
ISSN
2474-0527