Journal article
Angiotensin Blockade Modulates the Activity of PD1/L1 Inhibitors in Metastatic Urothelial Carcinoma
Abstract
BACKGROUND: The renin-angiotensin system is involved in the regulation of angiogenesis and cell proliferation. Angiotensin inhibition may improve drug delivery by enhancing tumor perfusion partly by downregulating transforming growth factor (TGF)-β. Because TGF-β is associated with resistance in patients with metastatic urothelial carcinoma (mUC) receiving programmed cell death protein 1/programmed cell death ligand 1 (PD1/L1) inhibitors, we …
Authors
Jain RK; Skelton Iv WP; Pond GR; Naqvi M; Kim Y; Curran C; Freeman D; Nuzzo PV; Alaiwi SA; Nassar AH
Journal
Clinical Genitourinary Cancer, Vol. 19, No. 6, pp. 540–546
Publisher
Elsevier
Publication Date
December 2021
DOI
10.1016/j.clgc.2021.04.002
ISSN
1558-7673