Conference
Impact of angiotensin inhibitors on pathologic complete response with neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer (MIBC).
Abstract
432
Background: The renin-angiotensin system (RAS) is involved in regulation of angiogenesis, cell proliferation, desmoplasia and immunosuppression. Angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) may have antitumor effects partly by inhibiting transforming growth factor (TGF)-β, a major resistance mechanism in bladder cancer. Methods: Patients (pts) with muscle invasive bladder cancer …
Authors
Thomas J; Pond GR; Curran C; Freeman D; Ravi P; Mossanen M; Preston MA; Steele GS; Mantia C; McGregor BA
Volume
39
Pagination
pp. 432-432
Publisher
American Society of Clinical Oncology (ASCO)
Publication Date
February 20, 2021
DOI
10.1200/jco.2021.39.6_suppl.432
Conference proceedings
Journal of Clinical Oncology
Issue
6_suppl
ISSN
0732-183X