Conference
Impact of angiotensin blockade on response to PD1/L1 inhibitors for patients with metastatic urothelial carcinoma (mUC).
Abstract
453
Background: The renin-angiotensin system (RAS) is involved in regulation of angiogenesis and cell proliferation. Preclinical data also indicate that angiotensin inhibition may improve drug delivery by enhancing tumor perfusion partly by downregulating transforming growth factor (TGF)-β. Since (TGF)-β appears to be associated with resistance in patients (pts) with metastatic urothelial carcinoma (mUC) receiving PD1/L1 …
Authors
Skelton WP; Jain RK; Curran C; Pond GR; Naqvi SMH; Kim Y; Nuzzo PV; Alaiwi SA; Nassar A; Jain RK
Volume
39
Pagination
pp. 453-453
Publisher
American Society of Clinical Oncology (ASCO)
Publication Date
February 20, 2021
DOI
10.1200/jco.2021.39.6_suppl.453
Conference proceedings
Journal of Clinical Oncology
Issue
6_suppl
ISSN
0732-183X