Journal article
Interleukin-15 and Natural Killer and NKT Cells Play a Critical Role in Innate Protection against Genital Herpes Simplex Virus Type 2 Infection
Abstract
Interleukin-15 (IL-15), natural killer (NK) cells, and NK T (NKT) cells, components of the innate immune system, are known to contribute to defense against pathogens, including viruses. Here we report that IL-15(-/-) (NK(-) and NKT(-/+)) mice and RAG-2(-/-)/gamma(c)(-/-) (NK(-) and NKT(-)) mice that lack all lymphoid cells were very susceptible to vaginal infection with a low dose of herpes simplex virus type 2 (HSV-2). IL-15(-/-) and …
Authors
Ashkar AA; Rosenthal KL
Journal
Journal of Virology, Vol. 77, No. 18, pp. 10168–10171
Publisher
American Society for Microbiology
Publication Date
September 15, 2003
DOI
10.1128/jvi.77.18.10168-10171.2003
ISSN
0022-538X