Journal article
Effect of ERCC-1 overexpression on sensitivity of Chinese hamster ovary cells to DNA damaging agents.
Abstract
Previous studies of ERCC-1 gene expression levels in chronic lymphocytic leukemia and ovarian carcinoma tumor specimens indicated that increased gene expression may correlate with a lack of response to the alkylating agents, melphalan, and cis-diamminedichloroplatinum (II). In order to demonstrate direct involvement of the ERCC-1 protein in repair of melphalan lesions, the ERCC-1 defective Chinese hamster ovary cell line UV20 was transfected …
Authors
Bramson J; Panasci LC
Journal
Cancer Research, Vol. 53, No. 14, pp. 3237–3240
Publication Date
July 15, 1993
ISSN
0008-5472