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Epitope discovery in West Nile virus infection:...
Journal article

Epitope discovery in West Nile virus infection: Identification and immune recognition of viral epitopes

Abstract

Cytotoxic T lymphocytes (CTL) play an important role in the control and elimination of infection by West Nile virus (WNV), yet the class I human leukocyte antigen (HLA)-presented peptide epitopes that enable CTL recognition of WNV-infected cells remain uncharacterized. The goals of this work were first to discover the peptide epitopes that distinguish the class I HLA of WNV-infected cells and then to test the T cell reactivity of newly …

Authors

McMurtrey CP; Lelic A; Piazza P; Chakrabarti AK; Yablonsky EJ; Wahl A; Bardet W; Eckerd A; Cook RL; Hess R

Journal

Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 8, pp. 2981–2986

Publisher

Proceedings of the National Academy of Sciences

Publication Date

February 26, 2008

DOI

10.1073/pnas.0711874105

ISSN

0027-8424